Anti-NLRP7 antibody (ab105405)
Key features and details
- Rabbit polyclonal to NLRP7
- Suitable for: IHC-P, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NLRP7 antibody
See all NLRP7 primary antibodies -
Description
Rabbit polyclonal to NLRP7 -
Host species
Rabbit -
Specificity
At least four isoforms of NLRP7 are known to exist; this antibody will recognize all of them. This antibody is predicted to not cross-react with other NLRP family members. -
Tested applications
Suitable for: IHC-P, ICC/IF, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human NLRP7 (N terminal).
Database link: Q8WX94 -
Positive control
- Human brain tissue lysate, K562 cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab105405 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 10 µg/ml.
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ICC/IF |
Use a concentration of 20 µg/ml.
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 112 kDa.
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Notes |
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IHC-P
Use a concentration of 10 µg/ml. |
ICC/IF
Use a concentration of 20 µg/ml. |
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 112 kDa. |
Target
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Function
Inhibits CASP1/caspase-1-dependent IL1B secretion. -
Tissue specificity
Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle. -
Involvement in disease
Defects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi. -
Sequence similarities
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. - Information by UniProt
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Database links
- Entrez Gene: 199713 Human
- Omim: 609661 Human
- SwissProt: Q8WX94 Human
- Unigene: 351118 Human
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Alternative names
- CLR19.4 antibody
- FLJ94610 antibody
- HYDM antibody
see all
Images
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All lanes : Anti-NLRP7 antibody (ab105405) at 2 µg/ml
Lane 1 : K562 cell lysate
Lane 2 : K562 cell lysate with Blocking peptide
Predicted band size: 112 kDa -
Immunohistochemistry of Human brain tissue with ab105405 at 10 μg/mL.
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Immunofluorescence of NLRP7 in Human brain tissue with ab105405 at 20 ug/mL.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab105405 has been referenced in 1 publication.
- Bednash JS et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun 8:15203 (2017). WB, FM ; Human . PubMed: 28492230