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Rabbit polyclonal to NLRP7
At least four isoforms of NLRP7 are known to exist; this antibody will recognize all of them. This antibody is predicted to not cross-react with other NLRP family members.
Synthetic peptide corresponding to Human NLRP7 (N terminal).
Database link: Q8WX94
- Human brain tissue lysate, K562 cell lysate
Shipped at 4°C. Store at +4°C.
Preservative: 0.02% Sodium Azide
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Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
||Use a concentration of 10 µg/ml.
||Use a concentration of 20 µg/ml.
||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 112 kDa.
Inhibits CASP1/caspase-1-dependent IL1B secretion.
Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
Involvement in disease
Defects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
Information by UniProt
- CLR19.4 antibody
- FLJ94610 antibody
- HYDM antibody
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