Overview

  • Product name
  • Description
    Rabbit polyclonal to NLRP7
  • Specificity
    At least four isoforms of NLRP7 are known to exist; this antibody will recognize all of them. This antibody is predicted to not cross-react with other NLRP family members.
  • Tested applications
    Suitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human NLRP7 (N terminal).
    Database link: Q8WX94

  • Positive control
    • Human brain tissue lysate, K562 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 112 kDa.

Target

  • Function
    Inhibits CASP1/caspase-1-dependent IL1B secretion.
  • Tissue specificity
    Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
  • Involvement in disease
    Defects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.
  • Sequence similarities
    Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • CLR19.4 antibody
    • FLJ94610 antibody
    • HYDM antibody
    • MGC126470 antibody
    • MGC126471 antibody
    • NACHT, leucine rich repeat and PYD containing 7 antibody
    • NACHT, LRR and PYD containing protein 7 antibody
    • NACHT, LRR and PYD domains containing protein 7 antibody
    • NACHT, LRR and PYD domains-containing protein 7 antibody
    • NALP7 antibody
    • NALP7_HUMAN antibody
    • NLR family, pyrin domain containing 7 antibody
    • NLRP7 antibody
    • NOD12 antibody
    • Nucleotide-binding oligomerization domain protein 12 antibody
    • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7 antibody
    • PAN7 antibody
    • PYPAF3 antibody
    • PYRIN-containing APAF1-like protein 3 antibody
    see all

Images

  • All lanes : Anti-NLRP7 antibody (ab105405) at 2 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate with Blocking peptide


    Predicted band size : 112 kDa
  • Immunohistochemistry of Human brain tissue with ab105405 at 10 μg/mL.

  • Immunofluorescence of NLRP7 in Human brain tissue with ab105405 at 20 ug/mL.

References

This product has been referenced in:
  • Bednash JS  et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun 8:15203 (2017). WB, FM ; Human . Read more (PubMed: 28492230) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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