Overview

  • Product nameAnti-NLRP7 antibody
    See all NLRP7 primary antibodies
  • Description
    Rabbit polyclonal to NLRP7
  • SpecificityAt least four isoforms of NLRP7 are known to exist; this antibody will recognize all of them. This antibody is predicted to not cross-react with other NLRP family members.
  • Tested applicationsSuitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human NLRP7 (N terminal).
    Database link: Q8WX94

  • Positive control
    • Human brain tissue lysate, K562 cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab105405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 112 kDa.

Target

  • FunctionInhibits CASP1/caspase-1-dependent IL1B secretion.
  • Tissue specificityExpressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
  • Involvement in diseaseDefects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.
  • Sequence similaritiesBelongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • CLR19.4 antibody
    • FLJ94610 antibody
    • HYDM antibody
    • MGC126470 antibody
    • MGC126471 antibody
    • NACHT, leucine rich repeat and PYD containing 7 antibody
    • NACHT, LRR and PYD containing protein 7 antibody
    • NACHT, LRR and PYD domains containing protein 7 antibody
    • NACHT, LRR and PYD domains-containing protein 7 antibody
    • NALP7 antibody
    • NALP7_HUMAN antibody
    • NLR family, pyrin domain containing 7 antibody
    • NLRP7 antibody
    • NOD12 antibody
    • Nucleotide-binding oligomerization domain protein 12 antibody
    • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7 antibody
    • PAN7 antibody
    • PYPAF3 antibody
    • PYRIN-containing APAF1-like protein 3 antibody
    see all

Anti-NLRP7 antibody images

  • All lanes : Anti-NLRP7 antibody (ab105405) at 2 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate with Blocking peptide


    Predicted band size : 112 kDa
  • Immunohistochemistry of Human brain tissue with ab105405 at 10 μg/mL.

  • Immunofluorescence of NLRP7 in Human brain tissue with ab105405 at 20 ug/mL.

References for Anti-NLRP7 antibody (ab105405)

ab105405 has not yet been referenced specifically in any publications.

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