Overview

  • Product nameAnti-NLRP7 antibody
    See all NLRP7 primary antibodies
  • Description
    Rabbit polyclonal to NLRP7
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region from the N-terminus of Human NLRP7.

  • Positive control
    • Human Spleen tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab117732 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 111 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionInhibits CASP1/caspase-1-dependent IL1B secretion.
  • Tissue specificityExpressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
  • Involvement in diseaseDefects in NLRP7 are the cause of hydatidiform mole (HYDM) [MIM:231090]. HYDM is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.
  • Sequence similaritiesBelongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • CLR19.4 antibody
    • FLJ94610 antibody
    • HYDM antibody
    • MGC126470 antibody
    • MGC126471 antibody
    • NACHT, leucine rich repeat and PYD containing 7 antibody
    • NACHT, LRR and PYD containing protein 7 antibody
    • NACHT, LRR and PYD domains containing protein 7 antibody
    • NACHT, LRR and PYD domains-containing protein 7 antibody
    • NALP7 antibody
    • NALP7_HUMAN antibody
    • NLR family, pyrin domain containing 7 antibody
    • NLRP7 antibody
    • NOD12 antibody
    • Nucleotide-binding oligomerization domain protein 12 antibody
    • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7 antibody
    • PAN7 antibody
    • PYPAF3 antibody
    • PYRIN-containing APAF1-like protein 3 antibody
    see all

Anti-NLRP7 antibody images

  • ab117732 at 5 µg/ml staining NLRP7 in Formalin-Fixed, Paraffin-Embedded Human Spleen.

References for Anti-NLRP7 antibody (ab117732)

ab117732 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (Hhuman Peripheral Blood Mononuclear Cells)
Gel Running Conditions Reduced Denaturing
Loading amount 20 µg
Treatment 10 ug/ml azithromycin
Specification Hhuman Peripheral Blood Mononuclear Cells
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 23°C
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Submitted Apr 26 2017

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"