Overview

  • Product name
  • Description
    Rabbit polyclonal to NME2
  • Specificity
    The peptide sequence for this antibody is 100% homologous with human NME1-NME2 (accession # Q32Q12). However, it has not been tested experimentally for reactivity to NME1.
  • Tested applications
    Suitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, from within N terminal amino acids 1-100 of Human NME2. Please note that the immunogen used is 100% conserved in NME1 and it is likely that this antibody will alos recognise NME1 (not tested).

  • Positive control
    • Mouse brain tissue lysate, Human breast carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab37627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 17 kDa (predicted molecular weight: 17 kDa).
IHC-P Use at an assay dependent concentration.

Target

  • Function
    Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
  • Tissue specificity
    Ubiquitously expressed.
  • Sequence similarities
    Belongs to the NDK family.
  • Cellular localization
    Cytoplasm. Nucleus. Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C myc purine binding transcription factor PUF antibody
    • C myc transcription factor antibody
    • C-myc purine-binding transcription factor PUF antibody
    • epididymis secretory sperm binding protein Li 155an antibody
    • HEL-S-155an antibody
    • Histidine protein kinase NDKB antibody
    • MGC111212 antibody
    • MGC2212 antibody
    • NDK B antibody
    • NDKB antibody
    • NDKB_HUMAN antibody
    • NDP kinase B antibody
    • NDPK B antibody
    • NDPKB antibody
    • NM23 H2 antibody
    • nm23-H2 antibody
    • NM23B antibody
    • NME/NM23 nucleoside diphosphate kinase 2 antibody
    • nme2 antibody
    • Non metastatic cells 2, protein (NM23B) expressed in antibody
    • non-metastatic cells 2, protein (NM23) expressed in antibody
    • Nucleoside diphosphate kinase B antibody
    • Nucleotide diphosphate kinase B antibody
    • PUF antibody
    see all

Images

  • Anti-NME2 antibody (ab37627) at 1/100 dilution + Mouse brain tissue lysate

    Secondary
    HRP-anti-rabbit

    Predicted band size : 17 kDa
    Observed band size : 17 kDa
    Additional bands at : 14 kDa,24 kDa,25 kDa,48 kDa. We are unsure as to the identity of these extra bands.
  • ab37627 at 1/50 dilution, staining NME2 in Human breast carcinoma by Immunohistochemistry, Formalin fixed Paraffin embedded tissue. ab37627 was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

References

ab37627 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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