Overview

  • Product nameNNC 711
  • Description
    Potent, selective GAT-1 inhibitor
  • Biological descriptionPotent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.

    Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity> 99%

Properties

    References for NNC 711 (ab120364)

    This product has been referenced in:
    • O'Connell AW  et al. Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric acid reuptake inhibitor. Eur J Pharmacol 424:37-44 (2001). Read more (PubMed: 11470258) »
    • Borden LA  et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 269:219-24 (1994). Read more (PubMed: 7851497) »
    • Suzdak PD  et al. NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur J Pharmacol 224:189-98 (1992). Read more (PubMed: 1468507) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"