Overview

  • Product name
    Anti-NNT1 antibody (Biotin)
    See all NNT1 primary antibodies
  • Description
    Rabbit polyclonal to NNT1 (Biotin)
  • Conjugation
    Biotin
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Highly pure (>98%) recombinant human NNT1

Properties

  • Form
    Lyophilised:Centrifuge vial prior to opening. Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • Purification notes
    ab83408 is affinity purified and sterile filtered.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab83408 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 0.25 - 1 µg/ml. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human NNT1.
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 25 kDa.

Target

  • Function
    Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.
  • Tissue specificity
    Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
  • Involvement in disease
    Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2) [MIM:610313]. Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.
  • Sequence similarities
    Belongs to the IL-6 superfamily.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • B cell stimulating factor 3 antibody
    • B-cell-stimulating factor 3 antibody
    • BSF 3 antibody
    • BSF-3 antibody
    • BSF3 antibody
    • Cardiotrophin like cytokine antibody
    • Cardiotrophin like cytokine factor 1 antibody
    • Cardiotrophin-like cytokine factor 1 antibody
    • CISS 2 antibody
    • CISS2 antibody
    • CLC antibody
    • CLCF 1 antibody
    • Clcf1 antibody
    • CLCF1_HUMAN antibody
    • Cold induced sweating syndrome 2 antibody
    • CRLF 1 associated cytokine like factor 1 antibody
    • CRLF1 associated cytokine like factor 1 antibody
    • Neurotrophin 1 antibody
    • Neurotrophin 1/B cell stimulating factor 3 antibody
    • Neurotrophin1 antibody
    • NNT 1 antibody
    • NNT-1 antibody
    • Novel neurotrophin 1 antibody
    • Novel neurotrophin-1 antibody
    • NR 6 antibody
    • NR6 antibody
    see all

References

ab83408 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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