Overview

  • Product name
  • Description
    Rabbit polyclonal to Nociceptin
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit, Horse, Dog, Pig
  • Immunogen

    Synthetic peptide:

    FGGFTGARKSARKLANQ

    , corresponding to internal sequence amino acids 130-146 of Human Nociceptin

Properties

Applications

Our Abpromise guarantee covers the use of ab100880 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/2000.
ICC 1/5000.

Target

  • Function
    Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
    Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
    Orphanin FQ2: Has potent analgesic activity.
  • Tissue specificity
    Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • Sequence similarities
    Belongs to the opioid neuropeptide precursor family.
  • Post-translational
    modifications
    Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • N/OFQ antibody
    • N23K antibody
    • N23K/N27K antibody
    • Nociceptin, included antibody
    • nocistatin antibody
    • Npnc1 antibody
    • OFQ antibody
    • OFQ/N antibody
    • Orphanin FQ antibody
    • Orphanin FQ2 antibody
    • Pnoc antibody
    • PNOC_HUMAN antibody
    • ppN/OFQ antibody
    • PPNOC antibody
    • pre-pro-N/OFQ antibody
    • prepronociceptin antibody
    • pronociceptin antibody
    • Propronociceptin antibody
    see all

Images

  • Dual labeling of Nociceptin (green) and enkephalin (red).

References

ab100880 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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