Anti-Nociceptin antibody (ab10276)

Overview

  • Product nameAnti-Nociceptin antibody
    See all Nociceptin primary antibodies
  • Description
    Guinea pig polyclonal to Nociceptin
  • Tested applicationsSuitable for: IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Non Human Primates
  • Immunogen

    Synthetic peptide:

    FGGFTGARKSARKLANQ

    , corresponding to amino acids 122-138 of Rat prepronociceptin, the precurser to nociceptin.

Properties

Applications

Our Abpromise guarantee covers the use of ab10276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/500.

Target

  • FunctionNociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
    Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
    Orphanin FQ2: Has potent analgesic activity.
  • Tissue specificityPredominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • Sequence similaritiesBelongs to the opioid neuropeptide precursor family.
  • Post-translational
    modifications
    Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • N/OFQ antibody
    • N23K antibody
    • N23K/N27K antibody
    • Nociceptin, included antibody
    • nocistatin antibody
    • Npnc1 antibody
    • OFQ antibody
    • OFQ/N antibody
    • Orphanin FQ antibody
    • Orphanin FQ2 antibody
    • Pnoc antibody
    • PNOC_HUMAN antibody
    • ppN/OFQ antibody
    • PPNOC antibody
    • pre-pro-N/OFQ antibody
    • prepronociceptin antibody
    • pronociceptin antibody
    • Propronociceptin antibody
    see all

Anti-Nociceptin antibody images

  • ab10276 at 1/500 dilution staining  Nociceptin in paraventricular nucleus by Immunohistochemistry.

References for Anti-Nociceptin antibody (ab10276)

ab10276 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (Adult Brain, 40 micron, floating)
Specification Adult Brain, 40 micron, floating
Fixative Perfuse 4% Paraformaldehyde
Permeabilization Yes - .25% Triton,
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: RT°C
Username

Dr. Joseph Dougherty

Verified customer

Submitted Aug 08 2007

Thank you for your enquiry. Below are the main differences between these two antibodies. Ab10276 - Guinea pig polyclonal to Nociceptin - was generated using the following inmmunogen: Synthetic peptide: FGGFTGARKSARKLANQ, corresponding to amino acids...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"