Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Sequence
      FGGFTGARKSARKLANQ
    • Amino acids
      1 to 17

Associated products

Specifications

Our Abpromise guarantee covers the use of ab38198 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • N/OFQ
    • N23K
    • N23K/N27K
    • Nociceptin, included
    • nocistatin
    • Npnc1
    • OFQ
    • OFQ/N
    • Orphanin FQ
    • Orphanin FQ2
    • Pnoc
    • PNOC_HUMAN
    • ppN/OFQ
    • PPNOC
    • pre-pro-N/OFQ
    • prepronociceptin
    • pronociceptin
    • Propronociceptin
    see all
  • Function
    Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
    Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
    Orphanin FQ2: Has potent analgesic activity.
  • Tissue specificity
    Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • Sequence similarities
    Belongs to the opioid neuropeptide precursor family.
  • Post-translational
    modifications
    Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab38198 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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