Overview

  • Product nameAnti-Nodal antibody
    See all Nodal primary antibodies
  • Description
    Rabbit polyclonal to Nodal
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (PSSPSPLAYM LSLYRDPLPR ADIIRSLQAE DVAVDGQNWT FAFDFSFLSQ) of Human NODAL (NP_060525).

  • Positive control
    • Human fetal thymus lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab99196 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionEssential for mesoderm formation and axial patterning during embryonic development.
  • Involvement in diseaseDefects in NODAL are the cause of visceral heterotaxy autosomal type 5 (HTX5) [MIM:270100]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia.
  • Sequence similaritiesBelongs to the TGF-beta family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • HTX5 antibody
    • MGC138230 antibody
    • Nodal antibody
    • Nodal Growth Differentiation Factor antibody
    • nodal homolog (mouse) antibody
    • Nodal homolog antibody
    • Nodal, Mouse, Homolog antibody
    • NODAL_HUMAN antibody
    see all

Anti-Nodal antibody images

  • Anti-Nodal antibody (ab99196) at 1 µg/ml + Human fetal thymus lysate at 10 µg

    Predicted band size : 39 kDa

References for Anti-Nodal antibody (ab99196)

ab99196 has not yet been referenced specifically in any publications.

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