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Product name
Nω-Nitro-L-arginine Methyl Ester hydrochloride (L-NAME)
Description
NOS inhibitor
Alternative names
- L-NAME
Biological description
Cell permeable NOS inhibitor. More soluble analogue of arginine. (pIC50 values are 4.3, 5.7 and 5.6 at human iNOS, nNOA and eNOS respectively).
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
Nω-Nitro-L-arginine methyl ester hydrochloride
Molecular Weight
269.69
Chemical structure
Molecular formula
C7H15N5O4.HCl
CAS Number
51298-62-5
Solubility
Soluble in water to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Nitric Oxide >> NOS >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Synthetase & synthase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Chemical Type >> Amino Acid
Biochemicals >> Product Range >> Just Add Water
References for Nω-Nitro-L-arginine Methyl Ester hydrochloride (L-NAME) (ab120136)
This product has been referenced in:
- Boer R et al. The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol 58:1026-34 (2000).Read more (PubMed: 11040050) »
- Moore PK & Handy RL Selective inhibitors of neuronal nitric oxide synthase--is no NOS really good NOS for the nervous system? Trends Pharmacol Sci 18:204-11 (1997).Read more (PubMed: 9226999) »
See all 3 publications for this product
Publishing research using ab120136? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"