Overview

  • Product name
  • Description
    Rabbit polyclonal to NOR1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-139 of Human NOR1 (UniProt ID: Q92570; NP_775292).

  • Positive control
    • NT2D1, U87-MG, IMR32 and MCF7 whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab155535 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 70 kDa.

Target

  • Function
    Binds to the B1A response-element.
  • Tissue specificity
    Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.
  • Involvement in disease
    Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
    Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR4 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • CHN antibody
    • Chondrosarcoma, extraskeletal myxoid, fused to EWS antibody
    • CSMF antibody
    • MINOR antibody
    • Mitogen induced nuclear orphan receptor antibody
    • Mitogen-induced nuclear orphan receptor antibody
    • Neuron derived orphan receptor 1 antibody
    • Neuron derived orphan receptor antibody
    • Neuron-derived orphan receptor 1 antibody
    • NOR1 antibody
    • Nr4a3 antibody
    • NR4A3_HUMAN antibody
    • Nuclear hormone receptor NOR-1 antibody
    • Nuclear hormone receptor NOR1 antibody
    • Nuclear receptor subfamily 4 group A member 3 antibody
    • TEC antibody
    • Translocated in extraskeletal chondrosarcoma antibody
    see all

Images

  • Anti-NOR1 antibody (ab155535) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

    Predicted band size: 70 kDa



    7.5% SDS PAGE

References

ab155535 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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