Overview

  • Product name
    Anti-NOSTRIN antibody
  • Description
    Rabbit polyclonal to NOSTRIN
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 217-247 of Human NOSTRIN (NP_443178.2, NP_001034813.2, NP_001165103.1, NP_001165102.1).

  • Positive control
    • HepG2 cell line and Mouse heart tissue lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab116374 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab116374 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 58 kDa.

Target

  • Function
    Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
  • Tissue specificity
    Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
  • Sequence similarities
    Contains 1 FCH domain.
    Contains 1 SH3 domain.
  • Domain
    The SH3 domain mediates interaction with NOS3, DNM2 and WASL.
    The FCH domain is necessary for membrane targeting.
  • Cellular localization
    Cell membrane. Cytoplasmic vesicle. Cytoplasm > cytoskeleton. Enriched in selected actin structures.
  • Information by UniProt
  • Database links
  • Alternative names
    • BM247 antibody
    • BM247 homolog antibody
    • DaIP2 antibody
    • eNOS-trafficking inducer antibody
    • mDaIP2 antibody
    • MGC20702 antibody
    • Nitric oxide synthase traffic inducer antibody
    • Nitric oxide synthase trafficker antibody
    • NOSTN_HUMAN antibody
    • Nostrin antibody
    • RP23-431D4.2 antibody
    see all

Images

  • Anti-NOSTRIN antibody (ab116374) at 1/100 dilution + HepG2 cell line lysate at 35 µg

    Predicted band size : 58 kDa
  • Anti-NOSTRIN antibody (ab116374) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

    Predicted band size : 58 kDa

References

ab116374 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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