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Product Name
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Notch 2 peptide
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide: RDASNHKRREPVGQD, corresponding to N terminal sequence of the cleaved form of Human Notch 2 (amino acids 1719/1733). This peptide was used as an immunogen for ab8926 - Notch 2 antibody.
BLAST 'RDASNHKRREPVGQD' with  or 
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Tested applications
(see key)
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BL
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Application notes
(see key)
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Recommended dilutions
BL: Use at an assay dependent concentration.
This peptide can be used with studies using ab8926.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Stem Cells >> Neural Stem Cells >> Surface Molecules
Stem Cells >> Neural Stem Cells >> Intracellular
Stem Cells >> Signaling Pathways >> Notch >> Nuclear
Stem Cells >> Signaling Pathways >> Notch >> Surface Molecules
Chromatin and Nuclear Signaling >> Transcription >> Other factors
Neuroscience >> Neurology process >> Notch Pathway
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Relevance
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Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.
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Storage buffer
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PBS with 0.02% sodium azide Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Sequence
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CRDASNHKRREPVGQD (aa1719 - 1733)
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Notch 2 peptide is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Notch 2
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Notch 2 peptide - more information
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Customer reviews (feedback) regarding Notch 2 peptide |
Customer FAQs regarding Notch 2 peptide |
Protocols for Notch 2 peptide |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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