Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceNotch1a is implicated in cell fate specifications during embryo development. It may be involved in the formation of the neural plate, notochord and brain vesicles. It is expressed in all cells in pregastrulation stages. During gastrulation it is differentially expressed, accumulating predominantly in the prechordal mesoderm and notochord. At the end of gastrulation, it is expressed along the anterior-posterior axis including the developing neural plate and differentiating mesoderm. It is also present in the developing brain and head regions.
Cellular localizationMembrane; Single-pass type I membrane protein.