FunctionPromotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Tissue specificityHighly expressed in adult T-cell leukemia cell line.
Sequence similaritiesBelongs to the PMAIP1 family.
DomainThe BH3 motif is essential for pro-apoptotic activity.
Adult T cell leukemia derived PMA responsive antibody
Immediate early response protein APR antibody
Immediate-early-response protein APR antibody
Phorbol 12 myristate 13 acetate induced protein 1 antibody
Phorbol-12-myristate-13-acetate-induced protein 1 antibody
PMA induced protein 1 antibody
PMA-induced protein 1 antibody
PMA-responsive gene antibody
Protein Noxa antibody
References for Anti-Noxa antibody (ab23563)
This product has been referenced in:
Pfeiffer S et al. Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury. Cell Death Dis5:e1456 (2014).
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