Overview

  • Product name
    Anti-Noxa antibody [EPR9735(B)]
    See all Noxa primary antibodies
  • Description
    Rabbit monoclonal [EPR9735(B)] to Noxa
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Noxa aa 1-100. The exact sequence is proprietary.

  • Positive control
    • LnCaP, HuT-78 and Jurkat cell lysates.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab140129 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 6 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function
      Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
    • Tissue specificity
      Highly expressed in adult T-cell leukemia cell line.
    • Sequence similarities
      Belongs to the PMAIP1 family.
    • Domain
      The BH3 motif is essential for pro-apoptotic activity.
    • Cellular localization
      Mitochondrion.
    • Information by UniProt
    • Database links
    • Alternative names
      • Adult T cell leukemia derived PMA responsive antibody
      • APR antibody
      • APR_HUMAN antibody
      • ATL-derived antibody
      • Immediate early response protein APR antibody
      • Immediate-early-response protein APR antibody
      • NOXA antibody
      • Phorbol 12 myristate 13 acetate induced protein 1 antibody
      • Phorbol-12-myristate-13-acetate-induced protein 1 antibody
      • PMA induced protein 1 antibody
      • PMA-induced protein 1 antibody
      • PMA-responsive gene antibody
      • Pmaip1 antibody
      • Protein Noxa antibody
      see all

    Images

    • All lanes : Anti-Noxa antibody [EPR9735(B)] (ab140129) at 1/1000 dilution

      Lane 1 : LnCaP cell lysate
      Lane 2 : HuT-78 cell lysate
      Lane 3 : Jurkat cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 6 kDa

    References

    This product has been referenced in:
    • Bogenberger J  et al. Combined venetoclax and alvocidib in acute myeloid leukemia. Oncotarget 8:107206-107222 (2017). Read more (PubMed: 29291023) »
    • Jia J  et al. Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS. J Invest Dermatol 136:1267-77 (2016). Read more (PubMed: 26902922) »

    See all 3 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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