Overview

  • Product name
  • Description
    Rabbit polyclonal to NOXA1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide corresponding to a region between amino acids 454-483 from the C terminal region of Human NOXA1.

  • Positive control
    • MDA-MB435 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab103007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 51 kDa.

Target

  • Function
    Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
  • Tissue specificity
    Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
  • Sequence similarities
    Belongs to the NCF2/NOXA1 family.
    Contains 1 OPR domain.
    Contains 1 SH3 domain.
    Contains 4 TPR repeats.
  • Developmental stage
    Expressed in fetal kidney.
  • Domain
    The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.
    The TPR repeats mediate interaction with RAC1.
  • Post-translational
    modifications
    Interaction with YWHAZ depends on phosphorylation by PKA.
  • Cellular localization
    Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen NY CO 31 antibody
    • Antigen NY-CO-31 antibody
    • FLJ25475 antibody
    • Inhibitory NADPH oxidase activator 1 antibody
    • MGC131800 antibody
    • NADPH oxidase activator 1 antibody
    • NCF2 like protein antibody
    • NCF2-like protein antibody
    • NOX activator 1 antibody
    • NOXA 1 antibody
    • Noxa1 antibody
    • NOXA1_HUMAN antibody
    • NY CO 31 antibody
    • p51 nox antibody
    • p51-nox antibody
    • p51NOX antibody
    • P67phox like factor antibody
    • P67phox-like factor antibody
    • SDCCAG31 antibody
    • Serologically defined colon cancer antigen 31 antibody
    see all

Images

  • Anti-NOXA1 antibody (ab103007) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

    Predicted band size : 51 kDa

References

This product has been referenced in:
  • Tesoriere L  et al. Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-?B-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1ß-exposed Caco-2 cells. Br J Nutr 111:415-23 (2014). Read more (PubMed: 23931157) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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