Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
Belongs to the NCF2/NOXA1 family. Contains 1 OPR domain. Contains 1 SH3 domain. Contains 4 TPR repeats.
Expressed in fetal kidney.
The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function. The TPR repeats mediate interaction with RAC1.
Interaction with YWHAZ depends on phosphorylation by PKA.
Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Tesoriere L et al. Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-?B-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1ß-exposed Caco-2 cells. Br J Nutr111:415-23 (2014).
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