FunctionFunctions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Tissue specificityWidely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
Sequence similaritiesBelongs to the NCF2/NOXA1 family. Contains 1 OPR domain. Contains 1 SH3 domain. Contains 4 TPR repeats.
Developmental stageExpressed in fetal kidney.
DomainThe SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function. The TPR repeats mediate interaction with RAC1.
Post-translational modificationsInteraction with YWHAZ depends on phosphorylation by PKA.
Cellular localizationCytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.