Anti-NPFF2 Receptor antibody - Extracellular domain (ab188780)

Overview

  • Product name
    Anti-NPFF2 Receptor antibody - Extracellular domain
    See all NPFF2 Receptor primary antibodies
  • Description
    Rabbit polyclonal to NPFF2 Receptor - Extracellular domain
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Cow, Dog, Pig, Monkey, Gorilla, Common marmoset, Elephant
  • Immunogen

    Synthetic peptide corresponding to Human NPFF2 Receptor. Sythetic peptide corresponds to 18 amino acids from the third extracellular domain. NP_004876.2.
    Database link: Q9Y5X5

  • Positive control
    • Human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 16 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • Tissue specificity
    Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • G protein coupled receptor 74 antibody
    • G protein coupled receptor HLWAR 77 antibody
    • G protein coupled receptor HLWAR77 antibody
    • G-protein coupled receptor 74 antibody
    • G-protein coupled receptor HLWAR77 antibody
    • GPR 74 antibody
    • GPR74 antibody
    • HLWAR 77 antibody
    • HLWAR77 antibody
    • Neuropeptide FF 2 antibody
    • Neuropeptide FF receptor 2 antibody
    • Neuropeptide G protein coupled receptor antibody
    • Neuropeptide G-protein coupled receptor antibody
    • NPFF 2 antibody
    • NPFF R2 antibody
    • NPFF2 antibody
    • NPFF2_HUMAN antibody
    • NPFFR 2 antibody
    • Npffr2 antibody
    • NPGPR antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue, labeling NPFF2 Receptor with ab188780 at 16 µg/ml.

References

ab188780 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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