Anti-NPHS2 antibody, prediluted (ab82107)

Overview

  • Product nameAnti-NPHS2 antibody, prediluted
    See all NPHS2 primary antibodies
  • Description
    Rabbit polyclonal to NPHS2, prediluted
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to the internal region of human NPHS2

  • Positive control
    • Kidney tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab82107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: Ready to use. Incubate for 30 mins at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol by boiling tissue section in 10mM Citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
    • Tissue specificityAlmost exclusively expressed in the podocytes of fetal and mature kidney glomeruli.
    • Involvement in diseaseDefects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2) [MIM:600995]. It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder.
    • Sequence similaritiesBelongs to the band 7/mec-2 family.
    • Cellular localizationCell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Nephrosis 2, idiopathic, steroid resistant (podocin) antibody
      • nephrosis 2, idiopathic, steroid resistant antibody
      • NPHS2 antibody
      • NPHS2 gene antibody
      • PDCN antibody
      • PODO_HUMAN antibody
      • Podocin antibody
      • SRN1 antibody
      see all

    Anti-NPHS2 antibody, prediluted images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human kidney tissue using prediluted ab82107.

    References for Anti-NPHS2 antibody, prediluted (ab82107)

    ab82107 has not yet been referenced specifically in any publications.

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