The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesWB: 1/500 - 1/1000. Detects bands of approximately 68 and 75 kDa (predicted molecular weight: 68 kDa).
ir.Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionThe ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.
Tissue specificityExpressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.