Overview

  • Product name
  • Description
    Goat polyclonal to NPR2L
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Xenopus laevis, Zebrafish
  • Immunogen

    Synthetic peptide:

    QYSNVYCPTPKV

    , corresponding to amino acids 240-251 of Human NPR2L (NP_006536.3).

  • Positive control
    • Human skeletal muscle lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution: 1/32000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 44 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
    • Tissue specificity
      Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.
    • Sequence similarities
      Belongs to the NPR2 family.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2810446G01Rik antibody
      • G21 protein antibody
      • Gene 21 protein antibody
      • Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody
      • Homologous to yeast nitrogen permease antibody
      • Nitrogen permease regulator 2-like protein antibody
      • Nitrogen permease regulator-like 2 (S. cerevisiae) antibody
      • NPR 2L antibody
      • NPR L2 antibody
      • NPR like 2 antibody
      • NPR2 antibody
      • NPR2 like antibody
      • NPR2-like protein antibody
      • NPR2L antibody
      • NPRL 2 antibody
      • NPRL2 antibody
      • NPRL2_HUMAN antibody
      • Tumor suppressor candidate 4 antibody
      • TUSC 4 antibody
      • TUSC 4 protein antibody
      • TUSC4 antibody
      • TUSC4 protein antibody
      see all

    Images

    References

    ab77349 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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