• Product name
  • Description
    Mouse polyclonal to NPR2L
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human NPR2L protein (AAH21984.1).

  • Positive control
    • WB: HeLa cell lysate; NPR2L transfected 293T cell lysate ICc/IF: HeLa cell



Our Abpromise guarantee covers the use of ab88691 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa.
ICC/IF Use a concentration of 10 µg/ml.


  • Function
    Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
  • Tissue specificity
    Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.
  • Sequence similarities
    Belongs to the NPR2 family.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2810446G01Rik antibody
    • G21 protein antibody
    • Gene 21 protein antibody
    • Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody
    • Homologous to yeast nitrogen permease antibody
    • Nitrogen permease regulator 2-like protein antibody
    • Nitrogen permease regulator-like 2 (S. cerevisiae) antibody
    • NPR 2L antibody
    • NPR L2 antibody
    • NPR like 2 antibody
    • NPR2 antibody
    • NPR2 like antibody
    • NPR2-like protein antibody
    • NPR2L antibody
    • NPRL 2 antibody
    • NPRL2 antibody
    • NPRL2_HUMAN antibody
    • Tumor suppressor candidate 4 antibody
    • TUSC 4 antibody
    • TUSC 4 protein antibody
    • TUSC4 antibody
    • TUSC4 protein antibody
    see all

Anti-NPR2L antibody images

  • Anti-NPR2L antibody (ab88691) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 44 kDa
    Observed band size : 44 kDa
  • All lanes : Anti-NPR2L antibody (ab88691) at 1 µg/ml

    Lane 1 : NPR2L transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Predicted band size : 44 kDa
    Observed band size : ~37 kDa (why is the actual band size different from the predicted?)
  • ab88691, at 10 µg/ml, staining NPR2L in HeLa cell by Immunofluorescence.

References for Anti-NPR2L antibody (ab88691)

This product has been referenced in:
  • Liu AY  et al. Relationship between tumor and peripheral blood NPRL2 mRNA levels in patients with colorectal adenoma and colorectal cancer. Cancer Biol Ther 15:489-95 (2014). Read more (PubMed: 24521741) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab88691.
Please use the links above to contact us or submit feedback about this product.


Sign up