Overview

  • Product nameAnti-NPTN antibody
    See all NPTN primary antibodies
  • Description
    Rabbit polyclonal to NPTN
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal region of Human NPTN.

  • Positive control
    • Human brain tissue.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
    Note: PBS (without Mg2+ and Ca2+)
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab110836 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab110836 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionProbable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity.
  • Tissue specificityIsoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level).
  • Sequence similaritiesContains 3 Ig-like (immunoglobulin-like) domains.
  • DomainSome isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationCell membrane. Enriched at post-synaptic density.
  • Information by UniProt
  • Database links
  • Alternative names
    • GP55 antibody
    • GP65 antibody
    • Neuroplastin antibody
    • np55 antibody
    • np65 antibody
    • Nptn antibody
    • NPTN_HUMAN antibody
    • SDFR1 antibody
    • SDR-1 antibody
    • SDR1 antibody
    • stromal cell derived factor receptor 1 antibody
    • Stromal cell-derived receptor 1 antibody
    see all

Anti-NPTN antibody images

  • ab110836 at 1/50 staining NPTN in paraffin-embedded Human brain tissue, left panel shows staining without immunizing peptide right panel shows staining with immunizing peptide.

References for Anti-NPTN antibody (ab110836)

ab110836 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"