Overview

  • Product name
    Anti-NR0B1 / Dax1 antibody
    See all NR0B1 / Dax1 primary antibodies
  • Description
    Rabbit polyclonal to NR0B1 / Dax1
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the C-terminal region of human NR0B1/ Dax1.

  • Positive control
    • Transfected 293 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab71022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa).
ELISA 1/1000.

Target

  • Function
    Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.
  • Involvement in disease
    Defects in NR0B1 are the cause of X-linked adrenal hypoplasia congenital (XL-AHC) [MIM:300200]; also known as X-linked Addison disease (AHX). XL-AHC is a developmental disorder of the adrenal gland that results in profound hormonal deficiencies and is lethal if untreated. It is characterized by the absence of the permanent zone of the adrenal cortex and by a structural disorganization of the glands. Hypogonadotropic hypogonadism (HHG) is frequently associated with this disorder. HHG is a condition resulting from or characterized by abnormally decreased gonadal function, with retardation of growth and sexual development.
    Defects in NR0B1 are the cause of 46,XY sex reversal type 2 (SRXY2) [MIM:300018]. It is a condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Note=XY individuals with a duplication of part of the short arm of the X chromosome and an intact SRY gene develop as females. The single X chromosome in these individuals does not undergo X-chromosome inactivation; therefore, these individuals presumably carry 2 active copies of genes, including the NR0B1 gene, in the duplicated region. Individuals with deletion of this region develop as males. Genes within the dosage-sensitive sex reversal region are, therefore, not essential for testis development, but, when present in a double dose, interfere with testis formation.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR0 subfamily.
  • Domain
    Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs.
  • Cellular localization
    Nucleus. Cytoplasm. Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AHC antibody
    • AHCH antibody
    • AHX antibody
    • DAX 1 antibody
    • DAX1 antibody
    • Dosage sensitive sex reversal antibody
    • DSS antibody
    • DSS AHC critical region on the X chromosome protein 1 antibody
    • DSS-AHC critical region on the X chromosome protein 1 antibody
    • GTD antibody
    • HHG antibody
    • Nr0b1 antibody
    • NR0B1_HUMAN antibody
    • NROB1 antibody
    • Nuclear hormone receptor antibody
    • Nuclear receptor 0B1 antibody
    • Nuclear receptor DAX 1 antibody
    • Nuclear receptor DAX-1 antibody
    • Nuclear receptor DAX1 antibody
    • Nuclear receptor subfamily 0 group B member 1 antibody
    • SRXY2 antibody
    see all

Images

  • All lanes : Anti-NR0B1 / Dax1 antibody (ab71022) at 1/50 dilution

    Lane 1 : Non-transfected 293 cell lysate
    Lane 2 : NR0B1 / Dax1 transfected 293 cell lysate

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 52 kDa
    Observed band size : 52 kDa

References

ab71022 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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