Overview

  • Product name
  • Description
    Rabbit polyclonal to NR0B2
  • Host species
    Rabbit
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Hamster, Cow, Pig, Monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human NR0B2. 16 amino acid peptide from ligand-binding domain. NP_068804.1.
    Database link: Q15466

  • Positive control
    • Human liver tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
  • Tissue specificity
    Liver. Low levels of expression were detected in heart and pancreas.
  • Involvement in disease
    Obesity
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR0 subfamily.
  • Post-translational
    modifications
    Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
  • Cellular localization
    Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • NR0B2 antibody
    • NR0B2_HUMAN antibody
    • Nr0b2a antibody
    • Nuclear receptor subfamily 0 group B member 2 antibody
    • Nuclear receptor subfamily 0, group B, member 2a antibody
    • Orphan nuclear receptor SHP antibody
    • SHP antibody
    • SHP-1 antibody
    • Shp1 antibody
    • Small heterodimer partner antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue, labeling NR0B2 with ab188970 at 4 µg/ml.

References

ab188970 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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