Overview

  • Product name
  • Description
    Rabbit polyclonal to NR0B2
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within the internal sequence amino acids 64-246 of Human NR0B2.

  • Positive control
    • Molt-4 cells, SW480 Xenograft

Properties

Applications

Our Abpromise guarantee covers the use of ab96605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.
IHC-P 1/100 - 1/250.
ICC/IF Use at an assay dependent concentration.

Target

  • Function
    Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
  • Tissue specificity
    Liver. Low levels of expression were detected in heart and pancreas.
  • Involvement in disease
    Obesity
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR0 subfamily.
  • Post-translational
    modifications
    Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
  • Cellular localization
    Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • NR0B2 antibody
    • NR0B2_HUMAN antibody
    • Nr0b2a antibody
    • Nuclear receptor subfamily 0 group B member 2 antibody
    • Nuclear receptor subfamily 0, group B, member 2a antibody
    • Orphan nuclear receptor SHP antibody
    • SHP antibody
    • SHP-1 antibody
    • Shp1 antibody
    • Small heterodimer partner antibody
    see all

Images

  • Anti-NR0B2 antibody (ab96605) at 1/1000 dilution + Molt-4 whole cell lysate at 30 µg

    Predicted band size : 28 kDa
  • Immunohistochemical analysis of paraffin-embedded SW480 Xenograft, using ab96605 at 1:100 dilution.

References

This product has been referenced in:
  • Prestin K  et al. Modulation of expression of the nuclear receptor NR0B2 (small heterodimer partner 1) and its impact on proliferation of renal carcinoma cells. Onco Targets Ther 9:4867-78 (2016). WB ; Human . Read more (PubMed: 27540300) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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