• Product nameAnti-NR2C2 antibody
    See all NR2C2 primary antibodies
  • Description
    Rabbit polyclonal to NR2C2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (FTSLNKEKIV TDQQTGQKIQ IVTAVDASGS PKQQFILTSP DGAGTGKVIL) of human NR2C2 (NP_003289).

  • Positive control
    • Fetal brain lysate.



Our Abpromise guarantee covers the use of ab83285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 65 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay, 1:312500.


  • FunctionOrphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR2 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Developmental stageTransiently repressed during the meiotic phase of spermatogenesis.
  • Post-translational
    Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the nonphosphorylated form preferentially recruits the coactivator, PCAF.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • FormThere are 2 isoforms produced by alternative splicing.
  • Alternative names
    • hTAK1 antibody
    • Nr2c2 antibody
    • NR2C2_HUMAN antibody
    • Nuclear hormone receptor TR4 antibody
    • Nuclear receptor subfamily 2 group C member 2 antibody
    • Orphan nuclear receptor TAK1 antibody
    • Orphan nuclear receptor TR4 antibody
    • TAK1 antibody
    • Testicular nuclear receptor 4 antibody
    • Testicular receptor 4 antibody
    • TR2R1 antibody
    • TR4 antibody
    • TR4 nuclear hormone receptor antibody
    see all

Anti-NR2C2 antibody images

  • Anti-NR2C2 antibody (ab83285) at 1 µg/ml + fetal brain lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 65 kDa
    Observed band size : 65 kDa

References for Anti-NR2C2 antibody (ab83285)

ab83285 has not yet been referenced specifically in any publications.

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