• Product nameAnti-NR2E3 antibody
    See all NR2E3 primary antibodies
  • Description
    Rabbit polyclonal to NR2E3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 169-198 of Human NR2E3 (NP_055064.1, NP_057430.1).

  • Positive control
    • WiDr cell line lysates.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab123091 purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab123091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 45 kDa.


  • FunctionOrphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M-and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
  • Tissue specificityEye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside.
  • Involvement in diseaseDefects in NR2E3 are a cause of enhanced S cone syndrome (ESCS) [MIM:268100]. ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration.
    Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37) [MIM:611131]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR2 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Post-translational
    Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ESCS antibody
    • MGC49976 antibody
    • NR2 E3 antibody
    • Nr2e3 antibody
    • NR2E3_HUMAN antibody
    • Nuclear receptor subfamily 2 group E member 3 antibody
    • Photoreceptor specific nuclear receptor antibody
    • Photoreceptor-specific nuclear receptor antibody
    • PNR antibody
    • Rd 7 antibody
    • Rd7 antibody
    • Retina specific nuclear receptor antibody
    • Retina-specific nuclear receptor antibody
    • Retinal degeneration 7 antibody
    • RNR antibody
    • RP37 antibody
    see all

Anti-NR2E3 antibody images

  • Anti-NR2E3 antibody (ab123091) at 1/100 dilution + WiDr cell line lysates at 35 µg

    Predicted band size : 45 kDa

References for Anti-NR2E3 antibody (ab123091)

ab123091 has not yet been referenced specifically in any publications.

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