• Product nameAnti-NR2E3 antibody
    See all NR2E3 primary antibodies
  • Description
    Mouse monoclonal to NR2E3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-323 of Human NR2E3


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG1
  • Light chain typeunknown
  • Research areas


Our Abpromise guarantee covers the use of ab56922 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionOrphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M-and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
    • Tissue specificityEye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside.
    • Involvement in diseaseDefects in NR2E3 are a cause of enhanced S cone syndrome (ESCS) [MIM:268100]. ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration.
      Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37) [MIM:611131]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant.
    • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR2 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Post-translational
      Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • ESCS antibody
      • MGC49976 antibody
      • NR2 E3 antibody
      • Nr2e3 antibody
      • NR2E3_HUMAN antibody
      • Nuclear receptor subfamily 2 group E member 3 antibody
      • Photoreceptor specific nuclear receptor antibody
      • Photoreceptor-specific nuclear receptor antibody
      • PNR antibody
      • Rd 7 antibody
      • Rd7 antibody
      • Retina specific nuclear receptor antibody
      • Retina-specific nuclear receptor antibody
      • Retinal degeneration 7 antibody
      • RNR antibody
      • RP37 antibody
      see all

    Anti-NR2E3 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56922 NR2E3 antibody at 1ug/ml. Predicted band size of immunogen is 62 kDa

    References for Anti-NR2E3 antibody (ab56922)

    ab56922 has not yet been referenced specifically in any publications.

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