FunctionTranscription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Tissue specificityUbiquitously expressed with strongest expression in skeletal muscle.
Sequence similaritiesBelongs to the NRF1/Ewg family.
Post-translational modificationsPhosphorylation enhances DNA binding.