• Product nameAnti-NRG2 antibody
    See all NRG2 primary antibodies
  • Description
    Rabbit polyclonal to NRG2
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptides selected from the C-term region (amino acids 834~850) and center region (amino acids 373~389) of human NRG2.

  • Positive control
    • Human hepatocarcinoma tissue.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesThis antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab60088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.


  • FunctionDirect ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
  • Tissue specificityRestricted to the cerebellum in the adult.
  • Sequence similaritiesBelongs to the neuregulin family.
    Contains 1 EGF-like domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • DomainThe cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.
    ERBB receptor binding is elicited entirely by the EGF-like domain.
  • Post-translational
    Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
    Extensive glycosylation precedes the proteolytic cleavage.
  • Cellular localizationSecreted and Cell membrane. Does not seem to be active.
  • Information by UniProt
  • Database links
  • Alternative names
    • Divergent of neuregulin 1 antibody
    • Divergent of neuregulin-1 antibody
    • Don 1 antibody
    • DON-1 antibody
    • Neural- and thymus-derived activator for ERBB kinases antibody
    • Neuregulin 2 antibody
    • Neuregulin-2 antibody
    • NRG-2 antibody
    • Nrg2 antibody
    • NRG2_HUMAN antibody
    • NTAK antibody
    • Pro NRG2 antibody
    • Pro-NRG2 antibody
    see all

Anti-NRG2 antibody images

  • Ab60088 (1/50-1/100) staining human NRG2 in human cancer tissue by immunohistochemistry using formalin fixed, paraffin embedd tissue.

    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

    HC = hepatocarcinoma.

References for Anti-NRG2 antibody (ab60088)

This product has been referenced in:
  • Sun M  et al. HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors. Clin Cancer Res 15:4829-37 (2009). IHC ; Human . Read more (PubMed: 19622585) »

See 1 Publication for this product

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