Overview

  • Product name
  • Description
    Rabbit polyclonal to NRG4
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A mixture of 2 KLH conjugated synthetic peptides selected from center and C terminal region of human NRG4.

  • Positive control
    • IHC-P: Human cancer tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab60090 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/20 - 1/100.

Target

  • Function
    Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
  • Sequence similarities
    Belongs to the neuregulin family.
    Contains 1 EGF-like domain.
  • Domain
    The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.
    ERBB receptor binding is elicited entirely by the EGF-like domain.
  • Post-translational
    modifications
    Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
    Extensive glycosylation precedes the proteolytic cleavage.
  • Cellular localization
    Secreted and Cell membrane. Does not seem to be active.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp779N0541 antibody
    • DKFZp779N1944 antibody
    • Heregulin 4 antibody
    • HRG4 antibody
    • Neuregulin 4 antibody
    • Neuregulin-4 antibody
    • NRG-4 antibody
    • NRG4 antibody
    • NRG4_HUMAN antibody
    • pro-neuregulin-4, membrane-bound isoform antibody
    • Pro-NRG4 antibody
    see all

Anti-NRG4 antibody images

  • Ab60090 (1/20 dilutio) staining NRG4 in formalin fixed, paraffin embedded human cancer tissue sections by immunohistochemistry. ab60090 was peroxidase conjugated to the secondary antibody, followed by AEC staining.
    BC = breast carcinoma.

References for Anti-NRG4 antibody (ab60090)

ab60090 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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