Overview

  • Product name
    NS309
  • Description
    Activates Ca2+-activated K+ channels
  • Biological description
    Potent activator of human Ca2+ -activated K+ channels of SK and IK types, selective over BK type channels (EC50 = 10 nM for increasing hIK current). At least 1000 times more potent than 1-EBIO (ab120258). Can be used in conjunction with CyPPA (ab120829) to distinguish SK1 and SK3 subtypes.
  • Purity
    > 98%

Properties

Associated products

References

This product has been referenced in:
  • Hougaard C  et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol 151:655-65 (2007). Read more (PubMed: 17486140) »
  • Pandita RK  et al. Urodynamic effects of intravesical administration of the new small/intermediate conductance calcium activated potassium channel activator NS309 in freely moving, conscious rats. J Urol 176:1220-4 (2006). Read more (PubMed: 16890729) »
  • Strøbaek D  et al. Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta 1665:1-5 (2004). Read more (PubMed: 15471565) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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