Overview

  • Product name
    NSC 405020
  • Description
    Non-catalytic MT1-MMP inhibitor
  • Alternative names
    • 3,4-Dichloro-N-(1-methylbutyl)-benzamide
    • 3,4-Dichloro-N-(pentan-2-yl)benzamide
    • NSC405020
  • Biological description

    MT1-MMP (Membrane type-1 matrix metalloproteinase) inhibitor (IC50 > 100 μM). Directly interacts with hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

  • Purity
    > 99%

Properties

  • Chemical name
    3,4-Dichloro-N-(1-methylbutyl)benzamide
  • Molecular weight
    260.16
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C12H15Cl2NO
  • CAS Number
    7497-07-6
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Thang ND  et al. Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma. PLoS One 9:e96945 (2014). Read more (PubMed: 24816914) »
  • Remacle AG  et al. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res 72:2339-49 (2012). Read more (PubMed: 22406620) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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