Overview

  • Product name
  • Description
    Rabbit polyclonal to NSE2
  • Specificity
    ab105363 is predicted to not crossreact with NSE1.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 15 amino acid peptide near the C terminus of Human NSE2 (NP_775956).

  • Positive control
    • 293 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 28 kDa.

Target

  • Function
    E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
  • Pathway
    Protein modification; protein sumoylation.
  • Sequence similarities
    Belongs to the NSE2 family.
    Contains 1 SP-RING-type zinc finger.
  • Post-translational
    modifications
    Sumoylated, possibly via autosumoylation.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C8orf36 antibody
    • E3 SUMO-protein ligase NSE2 antibody
    • hMMS21 antibody
    • hNSE2 antibody
    • methyl methanesulfonate sensitivity gene 21 antibody
    • MMS21 antibody
    • MMS21 homolog antibody
    • non-SMC element 2 antibody
    • Non-SMC element 2 homolog antibody
    • Non-structural maintenance of chromosomes element 2 homolog antibody
    • NSE2_HUMAN antibody
    • Nsmce2 antibody
    see all

Images

  • Lane 1 : Anti-NSE2 antibody (ab105363) at 0.5 µg/ml
    Lane 2 : Anti-NSE2 antibody (ab105363) at 1 µg/ml

    Lane 1 : 293 cell lysate
    Lane 2 : 293 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 28 kDa

References

ab105363 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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