Overview

  • Product name
  • Description
    Rabbit polyclonal to NSUN2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 426-455 of Human NSUN2 (NP_060225.4).

  • Positive control
    • Mouse spleen tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab107262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 86 kDa.

Target

  • Function
    RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation.
  • Sequence similarities
    Belongs to the methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
  • Post-translational
    modifications
    Phosphorylated at Ser-139 by Aurora-B/STK12 during mitosis, leading to abolish methyltransferase activity and the interaction with NPM1.
  • Cellular localization
    Nucleus > nucleolus. Cytoplasm. Concentrated in the nucleolus during interphase and distributed in the perichromosome and cytoplasm during mitosis.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5 methycytoisine methyltransferase antibody
    • D13Wsu123e antibody
    • FLJ20303 antibody
    • hTrm4 antibody
    • MISU antibody
    • Myc induced SUN domain containing protein antibody
    • NOL1/NOP2/Sun domain family 2 antibody
    • NOL1/NOP2/Sun domain family 2 protein antibody
    • NOL1/NOP2/Sun domain family member 2 antibody
    • NSUN 2 antibody
    • NSUN2 antibody
    • NSUN2_HUMAN antibody
    • SAKI antibody
    • Substrate of AIM1/Aurora kinase B antibody
    • TRM4 antibody
    • tRNA (cytosine 5 ) methyltransferase antibody
    • tRNA (cytosine 5 ) methyltransferase NSUN2 antibody
    • tRNA (cytosine(34)-C(5))-methyltransferase antibody
    • tRNA (cytosine-5-)-methyltransferase antibody
    • tRNA methyltransferase 4 homolo antibody
    • tRNA methyltransferase 4 homolog antibody
    see all

Images

  • Anti-NSUN2 antibody (ab107262) at 1/100 dilution + Mouse spleen tissue lysates at 35 µg

    Predicted band size : 86 kDa

References

ab107262 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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