Anti-NTAL antibody [NAP-07] (ab3992)

Overview

• Product nameAnti-NTAL antibody [NAP-07]
  See all NTAL primary antibodies
• Description
  Mouse monoclonal [NAP-07] to NTAL
• SpecificityThe antibody reacts with Non-T cell activation linker (NTAL) a 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
• Tested applicationsSuitable for: WB, IP, ICC/IFmore details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Recombinant fragment, corresponding to amino acids 91-244 of Human NTAL.

• Positive control
  • RAMOS human lymphoma cell lysate, Raji human lymphoma cell lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• Storage bufferPreservative: 15mM Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• Purity>95% by SDS-PAGE
• Purification notesPurified from hybridoma culture supernatant by protein A affinity chromatography.
• ClonalityMonoclonal
• Clone numberNAP-07
• IsotypeIgG1
• Research areas
  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

  • Immunology
  • Adaptive Immunity
  • T Cells
  • Non-CD

  • Signal Transduction
  • Signaling Pathway
  • Calcium Signaling
  • Other

Applications

Target

• FunctionInvolved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
• Tissue specificityHighly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
• Involvement in diseaseNote=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
• Post-translational
  modificationsPhosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
  May be polyubiquitinated.
• Cellular localizationCell membrane. Present in lipid rafts.

• Target information above from: UniProt accession Q9GZY6 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 7462 Human
  • Entrez Gene: 56743 Mouse
  • Omim: 605719 Human
  • SwissProt: Q9GZY6 Human
  • SwissProt: Q9JHL0 Mouse
  • Unigene: 726075 Human
  • Unigene: 391375 Mouse
• Alternative names
  • HSPC046 antibody
  • LAB antibody
  • LAT2 antibody

  • Linker for activation of B cells antibody
  • Linker for activation of B-cells antibody
  • Linker for activation of T cells family member 2 antibody
  • Linker for activation of T cells transmembrane adaptor 2 antibody
  • Linker for activation of T-cells family member 2 antibody
  • Membrane associated adapter molecule antibody
  • Membrane-associated adapter molecule antibody
  • Non T cell activation linker antibody
  • Non-T-cell activation linker antibody
  • NTAL_HUMAN antibody
  • WBSCR 5 antibody
  • Wbscr15 antibody
  • Williams Beuren syndrome chromosome region 15 antibody
  • Williams Beuren syndrome chromosome region 5 antibody
  • Williams-Beuren syndrome chromosomal region 15 protein antibody
  • Williams-Beuren syndrome chromosomal region 5 protein antibody
  • WSCR5 antibody

  see all