Anti-NTAL antibody [NAP-07] (Phycoerythrin) (ab27574)

Overview

  • Product nameAnti-NTAL antibody [NAP-07] (Phycoerythrin)
    See all NTAL primary antibodies
  • Description
    Mouse monoclonal [NAP-07] to NTAL (Phycoerythrin)
  • ConjugationPhycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment: cytoplasmic domain, amino acids 91-244 of human NTAL.

Properties

Applications

Our Abpromise guarantee covers the use of ab27574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/30.

Target

  • FunctionInvolved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
  • Tissue specificityHighly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
  • Involvement in diseaseNote=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • Post-translational
    modifications
    Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
    May be polyubiquitinated.
  • Cellular localizationCell membrane. Present in lipid rafts.
  • Information by UniProt
  • Database links
  • Alternative names
    • HSPC046 antibody
    • LAB antibody
    • LAT2 antibody
    • Linker for activation of B cells antibody
    • Linker for activation of B-cells antibody
    • Linker for activation of T cells family member 2 antibody
    • Linker for activation of T cells transmembrane adaptor 2 antibody
    • Linker for activation of T-cells family member 2 antibody
    • Membrane associated adapter molecule antibody
    • Membrane-associated adapter molecule antibody
    • Non T cell activation linker antibody
    • Non-T-cell activation linker antibody
    • NTAL_HUMAN antibody
    • WBSCR 5 antibody
    • Wbscr15 antibody
    • Williams Beuren syndrome chromosome region 15 antibody
    • Williams Beuren syndrome chromosome region 5 antibody
    • Williams-Beuren syndrome chromosomal region 15 protein antibody
    • Williams-Beuren syndrome chromosomal region 5 protein antibody
    • WSCR5 antibody
    see all

References for Anti-NTAL antibody [NAP-07] (Phycoerythrin) (ab27574)

ab27574 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab27574.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"