Anti-NTE antibody (ab110391)


  • Product nameAnti-NTE antibody
    See all NTE primary antibodies
  • Description
    Rabbit polyclonal to NTE
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthesized peptide derived from an internal region of Human NTE.

  • Positive control
    • Extracts from COLO205 cells



Our Abpromise guarantee covers the use of ab110391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 150 kDa.


  • FunctionPhospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
  • Tissue specificityExpressed in brain, placenta, kidney, neuron and skeletal muscle.
  • Involvement in diseaseDefects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39) [MIM:612020]; also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and lower extremity muscles.
  • Sequence similaritiesBelongs to the NTE family.
    Contains 3 cyclic nucleotide-binding domains.
    Contains 1 patatin domain.
  • Post-translational
  • Cellular localizationEndoplasmic reticulum membrane. Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC antibody
    • Neuropathy target esterase antibody
    • NTEMND antibody
    • Patatin like phospholipase domain containing 6 antibody
    • Patatin like phospholipase domain containing protein 6 antibody
    • Patatin-like phospholipase domain-containing protein 6 antibody
    • PLPL6_HUMAN antibody
    • Pnpla6 antibody
    • SPG39 antibody
    • sws antibody
    see all

Anti-NTE antibody images

  • All lanes : Anti-NTE antibody (ab110391) at 1/500 dilution

    Lane 1 : extracts from COLO205 cells
    Lane 2 : extracts from COLO205 cells with blocking peptide at 10 µg

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 150 kDa

References for Anti-NTE antibody (ab110391)

ab110391 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Mouse Recombinant protein (COS7 cell lysates overexpression murine NTE)
Loading amount 10 µg
Specification COS7 cell lysates overexpression murine NTE
Gel Running Conditions Reduced Denaturing (7,5 %)
Blocking step Milk as blocking agent for 12 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 4°C

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Submitted Jul 18 2012

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Expiration date: 15.September 2012

I am very pleased to hear you would like to accept our offer and test ab110391 in mouse. This code will give you: 1 free primary antibody or the value off your next ord...

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Thank you very much for your interest in ab110391.

I can confirm that the homology of the immunogen (aa121-151 of human PNPLA6 )to mouse is 96% ad therefore it is very likley that this antibody will recognize the mouse protein. This antibody ...

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