Overview

  • Product nameAnti-NTE antibody
    See all NTE primary antibodies
  • Description
    Rabbit polyclonal to NTE
  • Tested applicationsSuitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Zebrafish
  • Immunogen

    Synthetic peptide, corresponding to C terminal amino acids 1323-1348 of Zebrafish NTE

Properties

Applications

Our Abpromise guarantee covers the use of ab81387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 150 kDa.
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use a concentration of 0.5 - 1 µg/ml.

Target

  • FunctionPhospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
  • Tissue specificityExpressed in brain, placenta, kidney, neuron and skeletal muscle.
  • Involvement in diseaseDefects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39) [MIM:612020]; also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and lower extremity muscles.
  • Sequence similaritiesBelongs to the NTE family.
    Contains 3 cyclic nucleotide-binding domains.
    Contains 1 patatin domain.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localizationEndoplasmic reticulum membrane. Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 3.1.1.5 antibody
    • Neuropathy target esterase antibody
    • NTEMND antibody
    • Patatin like phospholipase domain containing 6 antibody
    • Patatin like phospholipase domain containing protein 6 antibody
    • Patatin-like phospholipase domain-containing protein 6 antibody
    • PLPL6_HUMAN antibody
    • Pnpla6 antibody
    • SPG39 antibody
    • sws antibody
    see all

References for Anti-NTE antibody (ab81387)

ab81387 has not yet been referenced specifically in any publications.

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Thank you for contacting us and your interest in our products.

The anti-NTE antibody (ab81387) has been raised against zebrafish NTE. Unfortunately, we do not have any purified zebrafish NTE or zebrafish lysates in our catalogue to offer to us...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"