Customer reviews and FAQs

Overview

  • Product name
    Anti-NTE antibody
    See all NTE primary antibodies
  • Description
    Rabbit polyclonal to NTE
  • Tested applications
    Suitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Zebrafish
  • Immunogen

    Synthetic peptide, corresponding to C terminal amino acids 1323-1348 of Zebrafish NTE

Properties

Applications

Our Abpromise guarantee covers the use of ab81387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 150 kDa.
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use a concentration of 0.5 - 1 µg/ml.

Target

  • Function
    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
  • Tissue specificity
    Expressed in brain, placenta, kidney, neuron and skeletal muscle.
  • Involvement in disease
    Defects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39) [MIM:612020]; also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and lower extremity muscles.
  • Sequence similarities
    Belongs to the NTE family.
    Contains 3 cyclic nucleotide-binding domains.
    Contains 1 patatin domain.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Endoplasmic reticulum membrane. Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
  • Information by UniProt
  • Database links
    • Alternative names
      • EC 3.1.1.5 antibody
      • Neuropathy target esterase antibody
      • NTEMND antibody
      • Patatin like phospholipase domain containing 6 antibody
      • Patatin like phospholipase domain containing protein 6 antibody
      • Patatin-like phospholipase domain-containing protein 6 antibody
      • PLPL6_HUMAN antibody
      • Pnpla6 antibody
      • SPG39 antibody
      • sws antibody
      see all

    References for Anti-NTE antibody (ab81387)

    ab81387 has not yet been referenced specifically in any publications.

    Publishing research using ab81387? Please let us know so that we can cite the reference in this datasheet.

    Product Wall

    Submit an abreview for ab81387 Submit a question for ab81387

    1 Abreview or Q&A

    10
    Votes: Highest First

    Hello Abcam Team,

    I would like to ask for a positive control to antibody NTE.

    Our customer bought antibody NTE, cat. No: ab81387 and they need to do a POSITIVE CONTROL.

    Can you offer me some product??

    Thank you very...

    Read More

    Thank you for contacting us and your interest in our products.

    The anti-NTE antibody (ab81387) has been raised against zebrafish NTE. Unfortunately, we do not have any purified zebrafish NTE or zebrafish lysates in our catalogue to offer to us...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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