Overview

  • Product name
    NU 7026
  • Description
    Novel, specific, reversible DNA-PK inhibitor
  • Biological description
    Novel, specific, reversible DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 = 0.23 μM). Increases G2/M arrest and inhibits double-strand break repair.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Baleriola J  et al. DNA-PK promotes the survival of young neurons in the embryonic mouse retina. Cell Death Differ 17:1697-706 (2010). Read more (PubMed: 20448641) »
  • Amrein L  et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J Pharmacol Exp Ther 321:848-55 (2007). Read more (PubMed: 17351105) »
  • Nutley BP  et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer 93:1011-8 (2005). Read more (PubMed: 16249792) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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