Overview

  • Product nameNU 7026
  • Description
    Novel, specific, reversible DNA-PK inhibitor
  • Biological descriptionNovel, specific, reversible DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 = 0.23 μM). Increases G2/M arrest and inhibits double-strand break repair.
  • Purity> 99%

Properties

    References for NU 7026 (ab120970)

    This product has been referenced in:
    • Baleriola J  et al. DNA-PK promotes the survival of young neurons in the embryonic mouse retina. Cell Death Differ 17:1697-706 (2010). Read more (PubMed: 20448641) »
    • Amrein L  et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J Pharmacol Exp Ther 321:848-55 (2007). Read more (PubMed: 17351105) »
    • Nutley BP  et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer 93:1011-8 (2005). Read more (PubMed: 16249792) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120970.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"