Overview

  • Product name
  • Description
    Rabbit polyclonal to NUAK2
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 47-233 of NUAK2 (Q9H093).

  • Positive control
    • NT2D1, IMR32, U-87 MG and MCF7 whole cell lysates; Human gastric carcinoma tissue.
  • General notes
    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab126048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 70 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function
    Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.
  • Information by UniProt
  • Database links
  • Form
    Involved in actin cytoskeleton organization.
  • Alternative names
    • DKFZp434J037 antibody
    • DKFZp686F01113 antibody
    • FLJ90349 antibody
    • NUAK family SNF1 like kinase 2 antibody
    • NUAK family SNF1-like kinase 2 antibody
    • Nuak2 antibody
    • NUAK2_HUMAN antibody
    • Omphalocele kinase 2 antibody
    • SNARK antibody
    • SNF1/AMP activated protein kinase antibody
    • SNF1/AMP kinase related kinase antibody
    • SNF1/AMP kinase-related kinase antibody
    see all

Images

  • Anti-NUAK2 antibody (ab126048) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg

    Predicted band size : 70 kDa
  • ab126048 at 1/500 dilution, staining NUAK2 in Paraffin-embedded Human Gastric carcinoma tissue by Immnunohistochemistry

References

ab126048 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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