Anti-NUAK2 antibody - Aminoterminal end (ab71398)

Overview

• Product name
  Anti-NUAK2 antibody - Aminoterminal end
  See all NUAK2 primary antibodies
• Description
  Rabbit polyclonal to NUAK2 - Aminoterminal end
• Tested applications
  Suitable for: WB, ELISAmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  KLH conjugated synthetic peptide selected from the N-terminal region of human NUAK2.

• Positive control
  • Transfected/ non-transfected 293 cell lysates.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage buffer
  Preservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• Purity
  Protein G purified
• Purification notes
  This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Microfilaments
  • Actin etc
  • Actin

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

  • Cancer
  • Invasion/microenvironment
  • Apoptosis
  • Other

  • Cancer
  • Cell Death
  • Apoptosis
  • Other

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

Target

• Function
  Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
• Sequence similarities
  Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
  Contains 1 protein kinase domain.
• Post-translational
  modifications
  Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.

• Target information above from: UniProt accession Q9H093 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 81788 Human
  • Omim: 608131 Human
  • SwissProt: Q9H093 Human
  • Unigene: 497512 Human
• Form
  Involved in actin cytoskeleton organization.
• Alternative names
  • DKFZp434J037 antibody
  • DKFZp686F01113 antibody
  • FLJ90349 antibody

  • NUAK family SNF1 like kinase 2 antibody
  • NUAK family SNF1-like kinase 2 antibody
  • Nuak2 antibody
  • NUAK2_HUMAN antibody
  • Omphalocele kinase 2 antibody
  • SNARK antibody
  • SNF1/AMP activated protein kinase antibody
  • SNF1/AMP kinase related kinase antibody
  • SNF1/AMP kinase-related kinase antibody

  see all

Protocols

• Western blot protocols