FunctionComponent of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Tissue specificityWidely expressed with highest expression in skeletal muscle.
Sequence similaritiesBelongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Developmental stageExpressed in fetal brain, lung, liver and kidney.
Cellular localizationNucleus. Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Enriched at the centrosomes during mitosis.