Nuclear Receptor Corepressor NCoR peptide (ab4997)

Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab4997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and N-CoR, catalog ab3482. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • hN CoR
    • hNCoR
    • KIAA1047
    • N CoR
    • N Cor/SMRT corepressor Rip13
    • N CoR1
    • N-CoR
    • N-CoR1
    • NCoR
    • NCOR 1
    • Ncor1
    • NCOR1_HUMAN
    • Nuclear receptor co repressor 1
    • Nuclear receptor corepressor 1
    • Retinoid X receptor interacting protein 13
    • RIP13
    • Rxrip13
    • thyroid hormone and retinoic acid receptor associated corepressor 1
    • TRAC 1
    • TRAC1
    see all
  • FunctionMediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
  • Sequence similaritiesBelongs to the N-CoR nuclear receptor corepressors family.
    Contains 2 SANT domains.
  • DomainThe N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
    The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.
  • Post-translational
    modifications
    Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Nuclear Receptor Corepressor NCoR peptide (ab4997)

ab4997 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"