Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.
Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.
Contains 1 RanBD1 domain.
Contains FG repeats.
Nucleus > nuclear pore complex. Nucleus membrane. Localizes to the nucleoplasmic fibrils of the nuclear pore complex.
Broggini-Tenzer A et al. Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation. Proteomics10:304-14 (2010).
Read more (PubMed: 19957288) »
González JM et al. Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. J Cell Biol183:653-66 (2008).
Read more (PubMed: 19015316) »