The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
FunctionMay function as a tissue-specific nuclear mRNA export factor.
Tissue specificityExpressed at high level in testis and at low level in a small number of tissues.
Sequence similaritiesBelongs to the NXF family. Contains 1 NTF2 domain. Contains 1 RRM (RNA recognition motif) domain.
DomainLacks C-terminal domain that mediates direct interactions with nucleoporins. Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain. The RNA-binding domain is a non-canonical RNP-type domain.
Cellular localizationNucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm.