Overview

  • Product name
  • Description
    Rabbit polyclonal to NYREN18
  • Tested applications
    Suitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from the C-terminal of NYREN18 (Human)

  • Positive control
    • COS7 cell extract (Western blot). Human tonsil tissue (IHC-P).

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab58401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
WB 1/500 - 1/1000. Detects a band of approximately 70 kDa (predicted molecular weight: 71 kDa).
IHC-P Use at an assay dependent concentration.

Target

  • Function
    Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
  • Tissue specificity
    Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
  • Sequence similarities
    Contains 3 UBA domains.
  • Cellular localization
    Nucleus. Predominantly nuclear.
  • Information by UniProt
  • Database links
  • Alternative names
    • BS4 antibody
    • NEDD8 ultimate buster 1 antibody
    • Negative regulator of ubiquitin like proteins 1 antibody
    • Negative regulator of ubiquitin-like proteins 1 antibody
    • NUB1 antibody
    • NUB1_HUMAN antibody
    • NUB1L antibody
    • NY REN 18 antibody
    • NYREN18 antibody
    • Renal carcinoma antigen NY-REN-18 antibody
    see all

Anti-NYREN18 antibody images

  • All lanes : Anti-NYREN18 antibody (ab58401) at 1/500 dilution

    Lane 1 : COS7 cell extract
    Lane 2 : COS7 cell extract with immunizing peptide


    Predicted band size : 71 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)
  • ab58401, at 1/50 dilution, staining human NYREN18 in tonsil tissue by immunohistochemistry, in the presence or absence of the immunizing peptide. Paraffin-embedded tissue.

References for Anti-NYREN18 antibody (ab58401)

ab58401 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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