Overview

  • Product nameO-1602
  • Description
    Potent, selective GPR55 agonist
  • Biological descriptionAnalog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, >30000 and >30000 nM for GPR55, CB1 and CB2 receptors, respectively). Inhibits mouse osteoclast formation in vitro, stimulates osteoclast polarization and resorption, causes activation of Rho and ERK1/2, and inhibits human neutrophil migration.
  • Purity> 98%
  • General notes

    Sold under license from Virginia Commonwealth University.

Properties

    References for O-1602 (ab120407)

    This product has been referenced in:
    • Whyte LS  et al. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A 106:16511-6 (2009). Read more (PubMed: 19805329) »
    • McHugh D  et al. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Mol Pharmacol 73:441-50 (2008). Read more (PubMed: 17965195) »
    • Ryberg E  et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 152:1092-101 (2007). Read more (PubMed: 17876302) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120407.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"