Biological descriptionAnalog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, >30000 and >30000 nM for GPR55, CB1 and CB2 receptors, respectively). Inhibits mouse osteoclast formation in vitro, stimulates osteoclast polarization and resorption, causes activation of Rho and ERK1/2, and inhibits human neutrophil migration.
General notesSold under license from Virginia Commonwealth University.
Storage instructionsStore at -20°C (desiccating conditions).
Solubility overviewSupplied in methyl acetate (10 mg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Whyte LS et al. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A106:16511-6 (2009).
Read more (PubMed: 19805329) »
McHugh D et al. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Mol Pharmacol73:441-50 (2008).
Read more (PubMed: 17965195) »